rho kinase inhibitor Search Results


92
Santa Cruz Biotechnology rockout
( A-D ) Whole-mount in situ hybridization analyses of 48 hpf wild type zebrafish embryos probed for rock1 (A,B) or rock2a (C,D) gene expression. (A,C) Lateral views, anterior to left. (B,D) Higher magnification dorsal views of the heads shown in panels A,C. ( E,G,I,K ) Stereoscope transmitted light images of DMSO-treated control sibling (E,I) or 25 μM (G) or 50 μM (K) Rock1/2 inhibitor <t>(Rockout)-treated</t> 50 hpf Tg(kdrl:EGFP), Tg(gata1a:DsRed) embryos. Arrowheads indicate hemorrhage. ( F,H,J,L ) Confocal images of cranial vessels (EGFP-positive, green) and blood cells (DsRed-positive, magenta) in the same embryos shown in panels E,G,I,K. Arrows indicate CtA defects, arrowheads indicate hemorrhage. ( M,N ) Quantitation of the percentage of 52 hpf Rockout-treated (light grey columns) or DMSO-treated (dark grey columns) sibling embryos with cranial hemorrhage (M) or cranial CtA defects (N). * P < 0.0001 compared to DMSO-treated controls, by Cochran-Mantel-Haenszel test. Mean ± SD is shown for each graph.
Rockout, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Santa Cruz Biotechnology rock inhibitor iii
( A-D ) Whole-mount in situ hybridization analyses of 48 hpf wild type zebrafish embryos probed for rock1 (A,B) or rock2a (C,D) gene expression. (A,C) Lateral views, anterior to left. (B,D) Higher magnification dorsal views of the heads shown in panels A,C. ( E,G,I,K ) Stereoscope transmitted light images of DMSO-treated control sibling (E,I) or 25 μM (G) or 50 μM (K) Rock1/2 inhibitor <t>(Rockout)-treated</t> 50 hpf Tg(kdrl:EGFP), Tg(gata1a:DsRed) embryos. Arrowheads indicate hemorrhage. ( F,H,J,L ) Confocal images of cranial vessels (EGFP-positive, green) and blood cells (DsRed-positive, magenta) in the same embryos shown in panels E,G,I,K. Arrows indicate CtA defects, arrowheads indicate hemorrhage. ( M,N ) Quantitation of the percentage of 52 hpf Rockout-treated (light grey columns) or DMSO-treated (dark grey columns) sibling embryos with cranial hemorrhage (M) or cranial CtA defects (N). * P < 0.0001 compared to DMSO-treated controls, by Cochran-Mantel-Haenszel test. Mean ± SD is shown for each graph.
Rock Inhibitor Iii, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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85
Santa Cruz Biotechnology pyridyl n
( A-D ) Whole-mount in situ hybridization analyses of 48 hpf wild type zebrafish embryos probed for rock1 (A,B) or rock2a (C,D) gene expression. (A,C) Lateral views, anterior to left. (B,D) Higher magnification dorsal views of the heads shown in panels A,C. ( E,G,I,K ) Stereoscope transmitted light images of DMSO-treated control sibling (E,I) or 25 μM (G) or 50 μM (K) Rock1/2 inhibitor <t>(Rockout)-treated</t> 50 hpf Tg(kdrl:EGFP), Tg(gata1a:DsRed) embryos. Arrowheads indicate hemorrhage. ( F,H,J,L ) Confocal images of cranial vessels (EGFP-positive, green) and blood cells (DsRed-positive, magenta) in the same embryos shown in panels E,G,I,K. Arrows indicate CtA defects, arrowheads indicate hemorrhage. ( M,N ) Quantitation of the percentage of 52 hpf Rockout-treated (light grey columns) or DMSO-treated (dark grey columns) sibling embryos with cranial hemorrhage (M) or cranial CtA defects (N). * P < 0.0001 compared to DMSO-treated controls, by Cochran-Mantel-Haenszel test. Mean ± SD is shown for each graph.
Pyridyl N, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 85/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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94
ReproCELL rho kinase inhibitor
( A-D ) Whole-mount in situ hybridization analyses of 48 hpf wild type zebrafish embryos probed for rock1 (A,B) or rock2a (C,D) gene expression. (A,C) Lateral views, anterior to left. (B,D) Higher magnification dorsal views of the heads shown in panels A,C. ( E,G,I,K ) Stereoscope transmitted light images of DMSO-treated control sibling (E,I) or 25 μM (G) or 50 μM (K) Rock1/2 inhibitor <t>(Rockout)-treated</t> 50 hpf Tg(kdrl:EGFP), Tg(gata1a:DsRed) embryos. Arrowheads indicate hemorrhage. ( F,H,J,L ) Confocal images of cranial vessels (EGFP-positive, green) and blood cells (DsRed-positive, magenta) in the same embryos shown in panels E,G,I,K. Arrows indicate CtA defects, arrowheads indicate hemorrhage. ( M,N ) Quantitation of the percentage of 52 hpf Rockout-treated (light grey columns) or DMSO-treated (dark grey columns) sibling embryos with cranial hemorrhage (M) or cranial CtA defects (N). * P < 0.0001 compared to DMSO-treated controls, by Cochran-Mantel-Haenszel test. Mean ± SD is shown for each graph.
Rho Kinase Inhibitor, supplied by ReproCELL, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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85
Santa Cruz Biotechnology rho kinase inhibitor iv
( A-D ) Whole-mount in situ hybridization analyses of 48 hpf wild type zebrafish embryos probed for rock1 (A,B) or rock2a (C,D) gene expression. (A,C) Lateral views, anterior to left. (B,D) Higher magnification dorsal views of the heads shown in panels A,C. ( E,G,I,K ) Stereoscope transmitted light images of DMSO-treated control sibling (E,I) or 25 μM (G) or 50 μM (K) Rock1/2 inhibitor <t>(Rockout)-treated</t> 50 hpf Tg(kdrl:EGFP), Tg(gata1a:DsRed) embryos. Arrowheads indicate hemorrhage. ( F,H,J,L ) Confocal images of cranial vessels (EGFP-positive, green) and blood cells (DsRed-positive, magenta) in the same embryos shown in panels E,G,I,K. Arrows indicate CtA defects, arrowheads indicate hemorrhage. ( M,N ) Quantitation of the percentage of 52 hpf Rockout-treated (light grey columns) or DMSO-treated (dark grey columns) sibling embryos with cranial hemorrhage (M) or cranial CtA defects (N). * P < 0.0001 compared to DMSO-treated controls, by Cochran-Mantel-Haenszel test. Mean ± SD is shown for each graph.
Rho Kinase Inhibitor Iv, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 85/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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93
Santa Cruz Biotechnology rock inhibitor
( A-D ) Whole-mount in situ hybridization analyses of 48 hpf wild type zebrafish embryos probed for rock1 (A,B) or rock2a (C,D) gene expression. (A,C) Lateral views, anterior to left. (B,D) Higher magnification dorsal views of the heads shown in panels A,C. ( E,G,I,K ) Stereoscope transmitted light images of DMSO-treated control sibling (E,I) or 25 μM (G) or 50 μM (K) Rock1/2 inhibitor <t>(Rockout)-treated</t> 50 hpf Tg(kdrl:EGFP), Tg(gata1a:DsRed) embryos. Arrowheads indicate hemorrhage. ( F,H,J,L ) Confocal images of cranial vessels (EGFP-positive, green) and blood cells (DsRed-positive, magenta) in the same embryos shown in panels E,G,I,K. Arrows indicate CtA defects, arrowheads indicate hemorrhage. ( M,N ) Quantitation of the percentage of 52 hpf Rockout-treated (light grey columns) or DMSO-treated (dark grey columns) sibling embryos with cranial hemorrhage (M) or cranial CtA defects (N). * P < 0.0001 compared to DMSO-treated controls, by Cochran-Mantel-Haenszel test. Mean ± SD is shown for each graph.
Rock Inhibitor, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 93 stars, based on 1 article reviews
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90
ReproCELL rho-associated protein kinase (rock)-inhibitor
( A-D ) Whole-mount in situ hybridization analyses of 48 hpf wild type zebrafish embryos probed for rock1 (A,B) or rock2a (C,D) gene expression. (A,C) Lateral views, anterior to left. (B,D) Higher magnification dorsal views of the heads shown in panels A,C. ( E,G,I,K ) Stereoscope transmitted light images of DMSO-treated control sibling (E,I) or 25 μM (G) or 50 μM (K) Rock1/2 inhibitor <t>(Rockout)-treated</t> 50 hpf Tg(kdrl:EGFP), Tg(gata1a:DsRed) embryos. Arrowheads indicate hemorrhage. ( F,H,J,L ) Confocal images of cranial vessels (EGFP-positive, green) and blood cells (DsRed-positive, magenta) in the same embryos shown in panels E,G,I,K. Arrows indicate CtA defects, arrowheads indicate hemorrhage. ( M,N ) Quantitation of the percentage of 52 hpf Rockout-treated (light grey columns) or DMSO-treated (dark grey columns) sibling embryos with cranial hemorrhage (M) or cranial CtA defects (N). * P < 0.0001 compared to DMSO-treated controls, by Cochran-Mantel-Haenszel test. Mean ± SD is shown for each graph.
Rho Associated Protein Kinase (Rock) Inhibitor, supplied by ReproCELL, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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90
SLIT2 LTD rho kinase-specific inhibitor y-27632
( A-D ) Whole-mount in situ hybridization analyses of 48 hpf wild type zebrafish embryos probed for rock1 (A,B) or rock2a (C,D) gene expression. (A,C) Lateral views, anterior to left. (B,D) Higher magnification dorsal views of the heads shown in panels A,C. ( E,G,I,K ) Stereoscope transmitted light images of DMSO-treated control sibling (E,I) or 25 μM (G) or 50 μM (K) Rock1/2 inhibitor <t>(Rockout)-treated</t> 50 hpf Tg(kdrl:EGFP), Tg(gata1a:DsRed) embryos. Arrowheads indicate hemorrhage. ( F,H,J,L ) Confocal images of cranial vessels (EGFP-positive, green) and blood cells (DsRed-positive, magenta) in the same embryos shown in panels E,G,I,K. Arrows indicate CtA defects, arrowheads indicate hemorrhage. ( M,N ) Quantitation of the percentage of 52 hpf Rockout-treated (light grey columns) or DMSO-treated (dark grey columns) sibling embryos with cranial hemorrhage (M) or cranial CtA defects (N). * P < 0.0001 compared to DMSO-treated controls, by Cochran-Mantel-Haenszel test. Mean ± SD is shown for each graph.
Rho Kinase Specific Inhibitor Y 27632, supplied by SLIT2 LTD, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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90
Bioaxone Inc rho kinase inhibitors
( A-D ) Whole-mount in situ hybridization analyses of 48 hpf wild type zebrafish embryos probed for rock1 (A,B) or rock2a (C,D) gene expression. (A,C) Lateral views, anterior to left. (B,D) Higher magnification dorsal views of the heads shown in panels A,C. ( E,G,I,K ) Stereoscope transmitted light images of DMSO-treated control sibling (E,I) or 25 μM (G) or 50 μM (K) Rock1/2 inhibitor <t>(Rockout)-treated</t> 50 hpf Tg(kdrl:EGFP), Tg(gata1a:DsRed) embryos. Arrowheads indicate hemorrhage. ( F,H,J,L ) Confocal images of cranial vessels (EGFP-positive, green) and blood cells (DsRed-positive, magenta) in the same embryos shown in panels E,G,I,K. Arrows indicate CtA defects, arrowheads indicate hemorrhage. ( M,N ) Quantitation of the percentage of 52 hpf Rockout-treated (light grey columns) or DMSO-treated (dark grey columns) sibling embryos with cranial hemorrhage (M) or cranial CtA defects (N). * P < 0.0001 compared to DMSO-treated controls, by Cochran-Mantel-Haenszel test. Mean ± SD is shown for each graph.
Rho Kinase Inhibitors, supplied by Bioaxone Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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90
Lucerna-Chem ag y-27632 rho kinase inhibitor
( A-D ) Whole-mount in situ hybridization analyses of 48 hpf wild type zebrafish embryos probed for rock1 (A,B) or rock2a (C,D) gene expression. (A,C) Lateral views, anterior to left. (B,D) Higher magnification dorsal views of the heads shown in panels A,C. ( E,G,I,K ) Stereoscope transmitted light images of DMSO-treated control sibling (E,I) or 25 μM (G) or 50 μM (K) Rock1/2 inhibitor <t>(Rockout)-treated</t> 50 hpf Tg(kdrl:EGFP), Tg(gata1a:DsRed) embryos. Arrowheads indicate hemorrhage. ( F,H,J,L ) Confocal images of cranial vessels (EGFP-positive, green) and blood cells (DsRed-positive, magenta) in the same embryos shown in panels E,G,I,K. Arrows indicate CtA defects, arrowheads indicate hemorrhage. ( M,N ) Quantitation of the percentage of 52 hpf Rockout-treated (light grey columns) or DMSO-treated (dark grey columns) sibling embryos with cranial hemorrhage (M) or cranial CtA defects (N). * P < 0.0001 compared to DMSO-treated controls, by Cochran-Mantel-Haenszel test. Mean ± SD is shown for each graph.
Y 27632 Rho Kinase Inhibitor, supplied by Lucerna-Chem ag, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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90
Merck KGaA rho-kinase (rock) inhibitor
( A-D ) Whole-mount in situ hybridization analyses of 48 hpf wild type zebrafish embryos probed for rock1 (A,B) or rock2a (C,D) gene expression. (A,C) Lateral views, anterior to left. (B,D) Higher magnification dorsal views of the heads shown in panels A,C. ( E,G,I,K ) Stereoscope transmitted light images of DMSO-treated control sibling (E,I) or 25 μM (G) or 50 μM (K) Rock1/2 inhibitor <t>(Rockout)-treated</t> 50 hpf Tg(kdrl:EGFP), Tg(gata1a:DsRed) embryos. Arrowheads indicate hemorrhage. ( F,H,J,L ) Confocal images of cranial vessels (EGFP-positive, green) and blood cells (DsRed-positive, magenta) in the same embryos shown in panels E,G,I,K. Arrows indicate CtA defects, arrowheads indicate hemorrhage. ( M,N ) Quantitation of the percentage of 52 hpf Rockout-treated (light grey columns) or DMSO-treated (dark grey columns) sibling embryos with cranial hemorrhage (M) or cranial CtA defects (N). * P < 0.0001 compared to DMSO-treated controls, by Cochran-Mantel-Haenszel test. Mean ± SD is shown for each graph.
Rho Kinase (Rock) Inhibitor, supplied by Merck KGaA, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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90
BioMimetic Therapeutics rho kinase inhibitor
( A-D ) Whole-mount in situ hybridization analyses of 48 hpf wild type zebrafish embryos probed for rock1 (A,B) or rock2a (C,D) gene expression. (A,C) Lateral views, anterior to left. (B,D) Higher magnification dorsal views of the heads shown in panels A,C. ( E,G,I,K ) Stereoscope transmitted light images of DMSO-treated control sibling (E,I) or 25 μM (G) or 50 μM (K) Rock1/2 inhibitor <t>(Rockout)-treated</t> 50 hpf Tg(kdrl:EGFP), Tg(gata1a:DsRed) embryos. Arrowheads indicate hemorrhage. ( F,H,J,L ) Confocal images of cranial vessels (EGFP-positive, green) and blood cells (DsRed-positive, magenta) in the same embryos shown in panels E,G,I,K. Arrows indicate CtA defects, arrowheads indicate hemorrhage. ( M,N ) Quantitation of the percentage of 52 hpf Rockout-treated (light grey columns) or DMSO-treated (dark grey columns) sibling embryos with cranial hemorrhage (M) or cranial CtA defects (N). * P < 0.0001 compared to DMSO-treated controls, by Cochran-Mantel-Haenszel test. Mean ± SD is shown for each graph.
Rho Kinase Inhibitor, supplied by BioMimetic Therapeutics, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


( A-D ) Whole-mount in situ hybridization analyses of 48 hpf wild type zebrafish embryos probed for rock1 (A,B) or rock2a (C,D) gene expression. (A,C) Lateral views, anterior to left. (B,D) Higher magnification dorsal views of the heads shown in panels A,C. ( E,G,I,K ) Stereoscope transmitted light images of DMSO-treated control sibling (E,I) or 25 μM (G) or 50 μM (K) Rock1/2 inhibitor (Rockout)-treated 50 hpf Tg(kdrl:EGFP), Tg(gata1a:DsRed) embryos. Arrowheads indicate hemorrhage. ( F,H,J,L ) Confocal images of cranial vessels (EGFP-positive, green) and blood cells (DsRed-positive, magenta) in the same embryos shown in panels E,G,I,K. Arrows indicate CtA defects, arrowheads indicate hemorrhage. ( M,N ) Quantitation of the percentage of 52 hpf Rockout-treated (light grey columns) or DMSO-treated (dark grey columns) sibling embryos with cranial hemorrhage (M) or cranial CtA defects (N). * P < 0.0001 compared to DMSO-treated controls, by Cochran-Mantel-Haenszel test. Mean ± SD is shown for each graph.

Journal: bioRxiv

Article Title: In vivo dissection of Rhoa function in vascular development using zebrafish

doi: 10.1101/2021.03.27.437282

Figure Lengend Snippet: ( A-D ) Whole-mount in situ hybridization analyses of 48 hpf wild type zebrafish embryos probed for rock1 (A,B) or rock2a (C,D) gene expression. (A,C) Lateral views, anterior to left. (B,D) Higher magnification dorsal views of the heads shown in panels A,C. ( E,G,I,K ) Stereoscope transmitted light images of DMSO-treated control sibling (E,I) or 25 μM (G) or 50 μM (K) Rock1/2 inhibitor (Rockout)-treated 50 hpf Tg(kdrl:EGFP), Tg(gata1a:DsRed) embryos. Arrowheads indicate hemorrhage. ( F,H,J,L ) Confocal images of cranial vessels (EGFP-positive, green) and blood cells (DsRed-positive, magenta) in the same embryos shown in panels E,G,I,K. Arrows indicate CtA defects, arrowheads indicate hemorrhage. ( M,N ) Quantitation of the percentage of 52 hpf Rockout-treated (light grey columns) or DMSO-treated (dark grey columns) sibling embryos with cranial hemorrhage (M) or cranial CtA defects (N). * P < 0.0001 compared to DMSO-treated controls, by Cochran-Mantel-Haenszel test. Mean ± SD is shown for each graph.

Article Snippet: Rockout (Rho Kinase Inhibitor III; Santa Cruz Biotechnology) was used to inhibit Rock1/2 activity .

Techniques: In Situ Hybridization, Gene Expression, Control, Quantitation Assay